The NANOCLEAN project helped the patent registration of “BIOGAS PRODUCTION”, which served as the first step to launch the APPLIED NANOPARTICLES S.L. (AppNps), a spin-off of the Catalan Institute of Nanotechnology (ICN2), the University Autonoma of Barcelona (UAB) and the Institut Català de Recerca i Estudis Avançats (ICREA). The principal aim of AppNps is to commercially exploit the patent application “biogas production” in the U.S and Europe by using iron oxide NP as supplements to develop the production of biogas. Another objective of AppNps is to develop projects on the production, characterization and commercialization of model NP and to consult relating their work with other possible industrial uses. For instance, AN explores the use of iron oxide NP in other applications, such as catalysis, environmental remediation, energy storage, drug, imaging contrast agent, bacteriostatic and bactericide substance or hyperthermia. The new spin-off has already created 15 new jobs.